Association between Obstructive Sleep Apnea and Cancer Incidence in a Large Multicenter Spanish Cohort

Francisco Campos-Rodriguez1Miguel A. Martinez-Garcia2,3Montserrat Martinez3,4Joaquin Duran-Cantolla3,5Monica de la Peña3,6María J. Masdeu3,7Monica Gonzalez8Felix del Campo3,9Inmaculada Gallego10Jose M. Marin3,11Ferran Barbe3,12Jose M. Montserrat3,13Ramon Farre3,14, and on behalf of the Spanish Sleep Network

1Respiratory Department and 10Oncology Department, Hospital Universitario de Valme, Sevilla, Spain 2Respiratory Department, Hospital Universitario y Politécnico La Fé, Valencia, Spain 3CIBER de Enfermedades Respiratorias, Bunyola, Spain 4Statistical Department, IRB Lleida, Lleida, Spain 5Research Department, Hospital Universitario Araba, Vitoria, Spain 6Respiratory Department, Hospital Universitario Son Espasses, Palma de Mallorca, Spain 7Respiratory Department, Hospital Parc Tauli, Sabadell, Spain 8Respiratory Department, Hospital Marques de Valdecilla, Santander, Spain 9Respiratory Department, Hospital Rio Hortega, Valladolid, Spain 11Respiratory Department, Hospital Miguel Servet, Zaragoza, Spain 12Respiratory Department, Hospital Arnau de Vilanova, IRB Lleida, Lleida, Spain 13Respiratory Department, Hospital Clinic, Barcelona, Spain; and 14Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Barcelona, Spain

Rationale: Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also associated with cancer incidence is unknown.

Continue Reading

Tongue and Lateral Upper Airway Movement with Mandibular Advancement

Elizabeth C. Brown, MBBS1; Shaokoon Cheng, PhD1,3; David K. McKenzie, PhD1,2; Jane E. Butler, PhD1,3; Simon C. Gandevia, DSc1,2; Lynne E. Bilston, PhD1,2

1Neuroscience Research Australia, Randwick, NSW, Australia; 2Prince of Wales Clinical School; 3School of Medical Sciences, University of New South Wales, Randwick NSW, Australia

Study Objectives: To characterize tongue and lateral upper airway movement and to image tongue deformation during mandibular advancement.

Continue Reading

Novel Sublingual Low-Dose Zolpidem Tablet Reduces Latency to Sleep Onset following Spontaneous Middle-of-the-Night Awakening in Insomnia in a Randomized, Double-Blind, Placebo-Controlled, Outpatient Study

Thomas Roth, PhD1, Andrew Krystal, MD2; Frank J. Steinberg, DO3; Nikhilesh N. Singh, PhD4; Margret Moline, PhD5

1Henry Ford Hospital, Detroit, MI; 2Duke University Medical Center, Durham, NC; 3Chief Medical Consultant, Transcept Pharmaceuticals, Inc., Point Richmond, CA; 4Transcept Pharmaceuticals, Inc., Point Richmond, CA;  5Purdue pharma L P Stamford, CT

Study Objectives: To evaluate efficacy and safety of 3.5-mg zolpidem tartrate sublingual tablets (ZST) on latency to sleep onset after middle-of-the night (MOTN) awakenings in patients with insomnia characterized by difficulty returning to sleep after MOTN awakenings.

Continue Reading

Symptoms of Aerophagia Are Common in Patients on Continuous Positive Airway Pressure Therapy and Are Related to the Presence of Nighttime Gastroesophageal Reflux

Kelly Shepherd, Ph.D.1,2; David Hillman, MB.BS.1; Peter Eastwood, Ph.D.1,2

1West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia;2School of Anatomy and Human Biology, University of Western Australia, Crawley, Australia

Study Objectives: Continuous positive airway pressure (CPAP), the mainstay treatment for obstructive sleep apnea (OSA), involves administration of air under pressure to the upper airway. A well-known but poorly understood side effect of positive airway pressure therapies is aerophagia, air entering the esophagus and stomach rather than the lungs. Gastric distension, a consequence of aerophagia, can increase gastroesophageal reflux (GER) by increasing transient lower esophageal sphincter relaxations, the most common cause of reflux. This study aimed to determine: (i) the prevalence of aerophagia symptoms in a group of OSA patients on CPAP therapy, and (ii) whether aerophagia symptoms are related to an increase in prevalence of GER symptoms.

Continue Reading

Effect of Short-Term Acclimatization to High Altitude on Sleep and Nocturnal Breathing

Yvonne Nussbaumer-Ochsner,MD1; Justyna Ursprung1; Christoph Siebenmann,MSc2; Marco Maggiorini,MD3; Konrad E. Bloch, MD1

1Pulmonary Division and Sleep Disorders Center, University Hospital of Zurich, and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland; 2Institute of Human Movement Sciences and Sports, Swiss Federal Institute of Technology, Zurich, Switzerland; 3Medical Intensive Care Unit, University Hospital of Zurich, and Center for Integrative Human Physiology, University of Zurich, Switzerland

Study Objective: Objective physiologic data on sleep and nocturnal breathing at initial exposure and during acclimatization to high altitude are scant. We tested the hypothesis that acute exposure to high altitude induces quantitative and qualitative changes in sleep and that these changes are partially reversed with acclimatization.

Continue Reading